An Experience with Kratom & Hydrocodone that if it really is a mu receptor agonist, it should work great in combination with other opioids. But it doesn't mix well with kratom, according to Swim. When I take hydrocodone it is usually in combination with kratom.
Kratom first then hydrocodone about an hour later when the kratom is kicking in. The idea being to achieve greater effect by mixing the two supposedly similar substances. Conclusively, it can be said that it Kratom and Hydrocodone is an effective combination, only the perfect dosage as per your body requirement. Kratom actually interferes with the opioid (ie:vicodin, tramadol etc) receptor sites in the brain.
It does not increase the effects or the "high" from. Hydrocodone (Vicodin… I usually take half of a 7.5 mg pill or so), really kicks up the kratom experience, and vice versa (I mixing acetaminophen and xanax tried vicodin on.